PD34 - Childhood mastocytosis: serum baseline total tryptase levels and extent of cutaneous disease as predictors of mast cell mediator release symptoms

Methods A total of 25 children (median age of onset 14,2 months (range, 0 mth–12ys) diagnosed with mastocytosis have been studied. Patients were classified according to the type of skin lesions following the WHO classification. Mastocytosis-related symptoms and data on specific triggering factors were systematically recorded for 3 years after diagnosis. Severity was graded according to standard recommendations. Serum baseline total tryptase (sbT) levels (CAP;Phadia Diagnostics) were measured at the time of referral. The extent of cutaneous disease was determined using the technique used to assess burns and is given as percentage of total body surface area (BSA).